Interleukin-12 in infectious diseases

Interleukin-12 in infectious diseases.

Interleukin-12 (IL-12) is a potent immunoregulatory cytokine that is crucially involved in a wide range of infectious diseases. In several experimental models of bacterial, parasitic, viral, and fungal infection, endogenous IL-12 is required for early control of infection and for generation and perhaps maintenance of acquired protective immunity, directed by T helper type 1 (Th1) cells and medi...

Corticosteroids in Infectious Diseases

Accumulated data based on experiences with curtico,teroids in the management uf infectious disea­ses, have proved that they are very dfective and ,afe drugs provided that are administered properly.  The Corticosteroids arc administered mainly be­c,1usc o; antitoxic, antiimflammatory a11d antiallcrgic effects, the cndotoxius are ncuturalized, generalized body reactions are diminished, damaged t...

12 th International Congress on Infectious Diseases

The two faces of interleukin 10 in human infectious diseases.

Resolution of infections depends on the host's ability to mount a protective immune response. However, an exacerbated response to infections may result in deleterious lesions. Consequently, immunoregulatory mechanisms are needed to control immune response and prevent infection-associated lesions. Interleukin 10 may be a major regulator of innate and adaptive immunity in vitro and in animals, bu...

[The role of interleukin-12 in immune-mediated rheumatic diseases].

OBJECTIVE IL-12 is a proinflammatory cytokine produced by different antigen presenting cells. It has been shown to exert a critical role in inducing Th1 phenotype, thus initiating cell-mediated immune responses, but the significance of IL-12 in rheumatic diseases is not clear. Aim of the study was to determine IL-12 serum levels in immune rheumatic diseases and to analyse the relationship of th...